Clone:
REA1187
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
BL-CAM, SIGLEC-2, Lyb-8

Specifications for CD22 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1187 recognizes the 150 kDa B cell–restricted glycoprotein CD22 on mice strains having the Lyb-8.2 alloantigen, e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, and SWR. Lyb-8.2 is expressed at mature levels on all B cell subsets. In bone marrow, CD22 is not detectable on pro–B cells, pre–B cells, and emerging IgM
+
B cells. CD22 plays a strong role in cell interactions and B cell activation.
Additional information: Clone REA1187 displays negligible binding to Fc receptors.

Alternative names

BL-CAM, SIGLEC-2, Lyb-8

Detailed product information

Technical specifications

CloneREA1187
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD22
Alternative names of antigenBL-CAM, SIGLEC-2, Lyb-8
Molecular mass of antigen [kDa]94
Distribution of antigenB cells
Entrez Gene ID12483
RRIDAB_2784068, AB_2784065, AB_2784064, AB_2784071, AB_2784070, AB_2784073, AB_2784072, AB_2784075, AB_2784074, AB_2784067, AB_2784066, AB_2784069

Resources for CD22 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD22 Antibody, anti-mouse, REAfinity™

Publications

  1. Symington, F. W. et al. (1982) Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody. Immunogenetics 16(5): 381-391
  2. Law, C. L. et al. (1994) Regulation of lymphocyte activation by the cell-surface molecule CD22. Immunol. Today 15(9): 442-449
  3. Erickson, L. D. et al. (1996) Differential expression of CD22 (Lyb8) on murine B cells. Immunogenetics 8(7): 1121-1129

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