Clone:
REA537
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
WIPF1, PRPL-2, WAS2, WASPIP, WIP

Specifications for WIP pS488 Antibody, anti-human, REAfinity™

Overview

Clone REA537 recognizes the human Wiskott-Aldrich syndrome protein-interacting protein (WIP) antigen phosphorylated at serine 488 (pS488). WIP is a multifunctional adaptor implicated in a wide range of cellular functions, including cell adhesion, migration and chemotaxis, T cell activation and proliferation, and intracellular pathogen motility. WIP functions through binding to both globular and filamentous actin and several regulators of actin dynamics. WIP can also bind to and regulate the function of the actin-nucleation-promoting factor cortactin. In cells of haematopoietic origin, WIP is an important regulator of Wiskott-Aldrich syndrome protein (WASP), the expression of which is restricted to cells of this lineage. WASP is indispensable for normal leukocyte function and its importance is highlighted in the congenital disorder Wiskott–Aldrich syndrome in which missense mutations in the WAS gene result in severe immunodeficiency. Phosphorylation represents a strong candidate for regulation of WIP function, as studies have reported serine/threonine phosphorylation of WIP on a number of residues. S488 has been reported to be phosphorylated in a PKCθ-dependent manner in response to T cell receptor activation.
Additional information: Clone REA537 displays negligible binding to Fc receptors.

Alternative names

WIPF1, PRPL-2, WAS2, WASPIP, WIP

Detailed product information

Technical specifications

CloneREA537
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenWIP pS488
Alternative names of antigenWIPF1, PRPL-2, WAS2, WASPIP, WIP
Molecular mass of antigen [kDa]51
Distribution of antigenother
Entrez Gene ID7456
RRIDAB_2654277, AB_2654278, AB_2654279, AB_2654276

References for WIP pS488 Antibody, anti-human, REAfinity™

Publications

  1. Ramesh, N. et al. (1997) WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc. Natl. Acad. Sci. U.S.A. 94(26): 14671-14676
  2. Vijayakumar, V. et al. (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. J. Cell. Sci. 128(2): 251-265

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