Clone:
REA470
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC

Specifications for TCR Vγ9 Antibody, anti-human, REAfinity™

Overview

Clone REA470 recognizes the human variable gamma 9 subunit of the γ/δ T cell receptor (TCR Vγ9). The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. γδ T cells represent unconventional lymphocytes that share characteristics of natural killer (NK) cells and T cells and often express regulatory NK receptors, thereby linking innate and adaptive immunity. Upon cross-linking CD94/NKG2A, antigenic activation of γδ T cells is down-modulated by inhibiting cell proliferation, cytokine production, and cytotoxicity. γδ T cells can detect target cells with patterns of MHC class I expression altered as a result of tumor transformation or viral infection, thus endowing them with a role in immunosurveillance originally attributed to NK cells only. Vγ9/Vδ2 T cells comprise the majority of peripheral human γδ T cells and are capable of responding to the microbial metabolite HMB-PP.
Additional information: Clone REA470 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA470
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
cynomolgus monkey (
Macaca fascicularis
)
,
chimpanzee (
Pan troglodytes
)
AntigenTCR Vγ9
Molecular mass of antigen [kDa]13
Distribution of antigenT cells
Entrez Gene ID6983
RRIDAB_2811563, AB_2857762, AB_2857750, AB_2857783, AB_2857774, AB_2653945, AB_2653946, AB_2653949, AB_2653950, AB_2811586

References for TCR Vγ9 Antibody, anti-human, REAfinity™

Publications

  1. Eberl, M. et al. (2005) Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). J. Leukoc. Biol. 77(1): 67-70
  2. Karunakaran, M. M. et al. (2014)
    Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (
    Vicugna pacos
    ).
    Immunogenetics 66(4): 243-254
  3. Pár, G. et al. (2002)
    Decrease in CD3-negative-CD8
    dim+
    and Vdelta2/Vgamma9 TcR
    +
    peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection.
    J. Hepatol. 37(4): 514-522

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