Clone:
REA497
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC

Specifications for TCR Vβ23 Antibody, anti-human, REAfinity™

Overview

Clone REA497 recognizes the human variable beta 23 subunit of the αβ T cell receptor (TCR Vβ23). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ23 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell–mediated immunity and underpins MHC restriction.
Additional information: Clone REA497 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA497
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTCR Vβ23
Molecular mass of antigen [kDa]13
Distribution of antigenT cells, thymocytes, T helper cells
Entrez Gene ID28564
RRIDAB_2653849, AB_2653850, AB_2653851, AB_2653852, AB_2653853, AB_2653854, AB_2653855, AB_2653856, AB_2653857, AB_2653848

References for TCR Vβ23 Antibody, anti-human, REAfinity™

Publications

  1. Born, W. et al. (1985) Rearrangement of T-cell receptor beta-chain genes during T-cell development. Proc. Natl. Acad. Sci. U.S.A. 82(9): 2925-2929
  2. van den Beemd, R. et al. (2000) Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 40(4): 336-345
  3. Trautmann, A. et al. (2003) Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation. Immunology 108(3): 305-312

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