Clone:
REA795
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
BK65A6.2, MSC

Specifications for SUSD2 Antibody, anti-human, REAfinity™

Overview

Clone REA795 recognizes the human sushi domain-containing protein 2 (SUSD2) antigen, a single-pass type I membrane protein which is expressed by bone marrow mesenchymal stem cells (MSCs), vessel-surrounding smooth muscle cells, and a few neoplastic cell lines. MSCs are multipotent stromal cells in various adult tissues that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. They represent a promising candidate cell population in regenerative medicine and their application in numerous cases demonstrate their therapeutic potential in the regeneration of all skeletal tissues, as well as of soft tissue organs. One particular advantage of MSCs is that they can be used when cells from the target tissue for regeneration are not available. SUSD2 expressing cells reside predominantly in a perivascular location in both basal and functional layers of endometrium. They are able to differentiate into adipocytes, osteocytes, chondrocytes, myocytes, and endothelial cells. SUSD2 is a single marker capable of purifying MSC and reconstituting endometrial stromal tissues
in vivo
.
Additional information: Clone REA795 displays negligible binding to Fc receptors.

Alternative names

BK65A6.2, MSC

Detailed product information

Technical specifications

CloneREA795
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSUSD2
Alternative names of antigenBK65A6.2, MSC
Molecular mass of antigen [kDa]88
Distribution of antigenstem cells, mesenchymal stem cells
Entrez Gene ID56241
RRIDAB_2653611, AB_2653612, AB_2653613, AB_2653614, AB_2653615, AB_2653616, AB_2653617, AB_2653610

References for SUSD2 Antibody, anti-human, REAfinity™

Publications

  1. Masuda, H. et al. (2012) A novel marker of human endometrial mesenchymal stem-like cells. Cell Transplant 21(10): 2201-2214
  2. Benz, K. et al. (2013)
    Maintenance of "stem cell" features of cartilage cell sub-populations during
    in vitro
    propagation.
    J. Transl. Med. 11: 27
  3. Ulrich, D. et al. (2014) Mesenchymal stem/stromal cells in post-menopausal endometrium. Hum. Reprod. 29(9): 1895-1905

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