StemMACS™ RepSox is a small molecule inhibitor of the TGFβ type I receptor ALK5.

Data and images for StemMACS™ RepSox

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Chemical structure of StemMACS™ RepSox
Chemical structure of StemMACS™ RepSox

Specifications for StemMACS™ RepSox

Overview

StemMACS™ RepSox is a small molecule inhibitor of the TGFβ type I receptor ALK5.

Detailed product information

Background information

StemMACS™ RepSox is an inhibitor of the TGF-β type I receptor ALK5. RepSox prevents autophosphorylation of the ALK5 receptor
1
. It has been shown to promote reprogramming efficiency by replacing Sox2 and inducing Nanog.

References for StemMACS™ RepSox

Publications

  1. Gellibert, F. et al. (2004) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J. Med. Chem. 47: 4494-4506