Clone:
REA159
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, ICFC
Alternative names:
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Specifications for STAT1 pY701 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA159 recognizes the Y701 phosphorylated form (pY701) of STAT1, a member of signal transducers and activators of transcription (STAT) family. STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon (IFN)-α, IFN-γ, EGF, PDGF, and interleukin (IL)-6). In response to binding of IFNs to their respective receptors, STAT1, which is receptor bound, is activated by phosphorylation at the Y701 residue by Janus protein tyrosine kinases (Jaks). Activation of STAT1 is accompanied by its dissociation from the receptor and formation of homodimer and complex with STAT2 and p48 followed by translocation of the homodimer and complex to the nucleus. STAT1 is involved in positive regulation of IFN-stimulated genes, negatively regulates expression of genes for thyrotropin receptor, matrix metalloproteinase 1, 2, 13, etc. and constitutive expression of caspases 1, 2, 3, and LMP2 genes. STAT1 expression is found ubiquitously.
Additional information: Clone REA159 displays negligible binding to Fc receptors.

Alternative names

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Detailed product information

Technical specifications

CloneREA159
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenSTAT1 pY701
Alternative names of antigenCANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Distribution of antigenother
RRIDAB_2653564, AB_2653565, AB_2653566, AB_2653567, AB_2653568, AB_2653569, AB_2801916

References for STAT1 pY701 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Gimeno, R. et al. (1996)
    STAT1 implication in the immune response to superantigens
    in vivo.
    J. Immunol. 156: 1378-1386
  2. Sikorski, K. et al. (2011) STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion. Am. J. Physiol., Cell Physiol. 300: C1337-C1344
  3. Mowen, K. et al. (1998) Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J. Biol. Chem. 273: 30073-30076
  4. ten Hoeve, J. et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 16: 5662-5668

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