Clone:
REA446
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
PDPN, Aggrus, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A

Specifications for Podoplanin Antibody, anti-human, REAfinity™

Overview

Clone REA446 recognizes the human podoplanin antigen, a 38–44 kDa mucin-type transmembrane protein which is also known as E11, GP38, OTS8, PA2.26, T1A, or aggrus. Podoplanin has a wide variety of functions including regulation of organ development, cell motility, tumorigenesis, and metastasis. It is expressed in multiple tissues during ontogeny and in adult, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. In lymphoid organs it is present in spleen four days postnatally. In adults, expression is detected on fibroblastic reticular cells, lymphatic endothelial cells, follicular dendritic cells in lymph node and spleen, and thymic medullary epithelial cells. Tumor cells often upregulate podoplanin as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis.
Additional information: Clone REA446 displays negligible binding to Fc receptors.

Alternative names

PDPN, Aggrus, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A

Detailed product information

Technical specifications

CloneREA446
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenPodoplanin
Alternative names of antigenPDPN, Aggrus, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A
Molecular mass of antigen [kDa]14
Distribution of antigenendothelial cells, dendritic cells, epithelial cells, osteoblasts, brain, heart, kidney, lung, lymph node, spleen
Entrez Gene ID10630
RRIDAB_2751407, AB_2811383, AB_2653265, AB_2653266, AB_2653267, AB_2653268, AB_2653269, AB_2653270, AB_2653271, AB_2653272, AB_2751425

References for Podoplanin Antibody, anti-human, REAfinity™

Publications

  1. Herzog, B. H. et al. (2013) Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502(7469): 105-109
  2. Zimmer, G. et al. (1999) Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem. J. 341(Pt 2): 277-284
  3. Astarita, J. L. et al. (2012) Expression of tumor necrosis factor receptor 2 characterizes TLR9-driven formation of interleukin-10-producing B cells. Front Immunol 12(3): 283

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