Clone:
REA1132
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
BCC7, LFS1, P53, TRP53

Specifications for p53 Antibody, anti-human, REAfinity™

Overview

Clone REA1132 recognizes the human cellular tumor antigen p53. The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death.
Additional information: Clone REA1132 displays negligible binding to Fc receptors.

Alternative names

BCC7, LFS1, P53, TRP53

Detailed product information

Technical specifications

CloneREA1132
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
Antigenp53
Alternative names of antigenBCC7, LFS1, P53, TRP53
Molecular mass of antigen [kDa]44
Distribution of antigenubiquitous, tumor cells, tumor, ubiquitous
Entrez Gene ID7157
RRIDAB_2857470, AB_2857471, AB_2857469

References for p53 Antibody, anti-human, REAfinity™

Publications

  1. Zakut-Houri, R. et al. (1985) Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4(5): 1251-1255
  2. Lamb, P. et al. (1986) Characterization of the human p53 gene. Mol. Cell. Biol. 6(5): 1379-1385
  3. Stiewe, T. (2007) The p53 family in differentiation and tumorigenesis. Nat. Rev. Cancer 7(3): 165-168