Clone:
REA973
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
p16-INK4, p16-INK4A, ARF, MTS1, CDKN2, CDK4l

Specifications for p16 Antibody, anti-human, REAfinity™

Overview

Clone REA973 recognizes the human p16 protein, a member of the cyclin-dependent kinases (CDKs), also known as cyclin-dependent kinase 4 inhibitor (CDKN2) or INK4A. p16 is a multiple tumor-suppressor protein that functions as a negative regulator of the proliferation of normal cells and tumorigenesis by forming heterodimers with CDK4 and CDK6. p16 is found in most of different cell types but it is not detected in brain or skeletal muscle.
Additional information: Clone REA973 displays negligible binding to Fc receptors

Alternative names

p16-INK4, p16-INK4A, ARF, MTS1, CDKN2, CDK4l

Detailed product information

Technical specifications

CloneREA973
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
Antigenp16
Alternative names of antigenp16-INK4, p16-INK4A, ARF, MTS1, CDKN2, CDK4l
Molecular mass of antigen [kDa]17
Distribution of antigenany cell type
Entrez Gene ID1029
RRIDAB_2727358, AB_2727418, AB_2727359, AB_2727419, AB_2727360, AB_2727417

References for p16 Antibody, anti-human, REAfinity™

Publications

  1. Serrano, M. et al. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366(6456): 704-707
  2. Okamoto, A. et al. (1994) Mutations and altered expression of p16INK4 in human cancer. Proc. Natl. Acad. Sci. U.S.A. 91(23): 11045-11049
  3. Bockstaele, L. et al. (2006) Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol. Cell. Biol. 26(13): 5070-5085
  4. Huang, X. et al. (2007) Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a. Biochem. Biophys. Res. Commun. 361(2): 287-293

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p16 Antibody, anti-human, REAfinity™

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