Clone:
REA129
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
CTNND1, CAS, CTNND, p120cas, p120ctn, p120

Specifications for p120 Catenin pT916 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA129 recognizes the T916-phosphorylated form of p120 Catenin, a prototypic member of subfamily of armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1–7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Furthermore, lack of p120 Catenin in mouse leads to tumor development, suggesting its further role as tumor supressor. Phosphorylation of p120 Catenin at multiple sites regulates its various functions and it can be phosphorylated by Src and various receptor tyrosine kinases.
Additional information: Clone REA129 displays negligible binding to Fc receptors.

Alternative names

CTNND1, CAS, CTNND, p120cas, p120ctn, p120

Detailed product information

Technical specifications

CloneREA129
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Antigenp120 Catenin pT916
Alternative names of antigenCTNND1, CAS, CTNND, p120cas, p120ctn, p120
RRIDAB_2653121, AB_2653122, AB_2653123, AB_2653124, AB_2653125, AB_2653126, AB_2653127, AB_2653120

References for p120 Catenin pT916 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Stairs, D. B. et al. (2011) Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell 19(4): 470-483
  2. Reynolds, A. B. et al. (2004) Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene 23(48): 7947-7956

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