Clone:
6D4
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2aκ
Applications:
FC
Alternative names:
MICB, PERB11.2, MICA, PERB11.1

Specifications for MICA/MICB Antibody, anti-human

Overview

The monoclonal antibody 6D4 recognizes MICA and MICB, which are transmembrane glycoproteins related to major histocompatibility complex (MHC) class I molecules. In contrast to other MHC class I proteins, MICA/B have no association with β2-microglobulin and do not bind peptides. They are ligands for NKG2D, which is expressed on NK cells and many T cells. MICA/B are expressed on endothelial cells and fibroblasts and are stress-induced in epithelial cells.

Alternative names

MICB, PERB11.2, MICA, PERB11.1

Detailed product information

Technical specifications

Clone6D4
Clonalitymonoclonal
Isotypemouse IgG2aκ
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenMICA/MICB
Alternative names of antigenMICB, PERB11.2, MICA, PERB11.1
Distribution of antigenendothelial cells, fibroblasts
RRIDAB_2652921, AB_2652922, AB_2652923, AB_2652924, AB_2652925, AB_2652926, AB_2652927, AB_2652928, AB_2652929, AB_2652930, AB_2652931, AB_2652932

References for MICA/MICB Antibody, anti-human

Publications

  1. Li, P. et al. (1999) Crystal structure of the MHC class I homolog MIC-A, a γδ T cell ligand. Immunity 10: 577-584
  2. Houchins, J. P. et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173(4): 1017-1020
  3. Bauer, S. et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729

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MICA/MICB Antibody, anti-human

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