Clone:
REA1041
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Specifications for Melanoma (MCSP) Antibody, anti-human, REAfinity™

Overview

Clone REA1041 recognizes the melanoma-associated chondroitin sulfate proteoglycan (MCSP) antigen, also known as high molecular weight melanoma-associated antigen. MCSP is expressed on the majority (>90%) of human melanoma tissues and melanoma cell lines but not on carcinoma cells, fibroblastoid cells, and cells of hematopoietic origin.
Additional information: Clone REA1041 displays negligible binding to Fc receptors.

Alternative names

CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Detailed product information

Technical specifications

CloneREA1041
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenMelanoma (MCSP)
Alternative names of antigenCSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Molecular mass of antigen [kDa]248
Distribution of antigenmelanoma
Entrez Gene ID1464
RRIDAB_2733679, AB_2733874, AB_2733875, AB_2733433, AB_2733434, AB_2733966, AB_2733967, AB_2734106, AB_2734107, AB_2733004, AB_2733005, AB_2733270, AB_2733271, AB_2733157, AB_2733158, AB_2733059, AB_2733060, AB_2734043, AB_2734044, AB_2733556, AB_2733557, AB_2733678

References for Melanoma (MCSP) Antibody, anti-human, REAfinity™

Publications

  1. Morgan, A. C. et al. (1981) Production and characterization of monoclonal antibody to a melanoma specific glycoprotein. Hybridoma 1: 27-36
  2. Bumol, T. F. and Reisfeld, R. A. (1982) Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells. Proc. Natl. Acad. Sci. U.S.A. 79(4): 1245-1249
  3. Bumol, T. F. et al. (1984) Biosynthetic studies of proteoglycans in human melanoma cells with a monoclonal antibody to a core glycoprotein of chondroitin sulfate proteoglycans. J. Biol. Chem. 259(20): 12733-12741
  4. Pluschke, G. et al. (1996) Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. Proc. Natl. Acad. Sci. U.S.A. 93(18): 9710-9715
  5. Benez, A. et al. (1999) Detection of circulating melanoma cells by immunomagnetic cell sorting. J. Clin. Lab. Anal. 13: 229-233
  6. Siewert, C. et al. (2001) Rapid enrichment and detection of melanoma cells from peripheral blood mononuclear cells by a new assay combining immunomagnetic cell sorting and immunocytochemical staining. Recent Results Cancer Res. 158: 51-60

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