Clone:
REA927
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
Pmel 17, Melanocyte protein PMEL, premelanosome protein, gp100

Specifications for Melanocyte PMEL Antibody, anti-human, REAfinity™

Overview

Clone REA927 recognizes the human Melanocyte PMEL antigen (Melanocyte premelanosome protein), which is located in fetal and neonatal melanocytes and junctional nevi. Melanocyte PMEL is a marker for melanocytic tumors such as melanomas, it is not expressed in normal tissues nor in carcinomas. Melanosome, also known as Melanocyte protein Pmel 17, plays an essential role in the biogenesis of melanosomes and maturation of melanosomes.
Additional Information: Clone REA927 displays negligible binding to Fc receptors.

Alternative names

Pmel 17, Melanocyte protein PMEL, premelanosome protein, gp100

Detailed product information

Technical specifications

CloneREA927
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenMelanocyte PMEL
Alternative names of antigenPmel 17, Melanocyte protein PMEL, premelanosome protein, gp100
Distribution of antigentumor cells, melanoma
RRIDAB_2857400, AB_2857401, AB_2857399

References for Melanocyte PMEL Antibody, anti-human, REAfinity™

Publications

  1. Gown, A. M. et al. (1986) Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes. Am. J. Pathol. 123(2): 195-203
  2. Kawakami, Y. et al. (1994) Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Natl. Acad. Sci. U.S.A. 91(14): 6458-6462
  3. Chi, A. et al. (2006) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J. Proteome Res. 11(5): 3135-3144
  4. Kodet, O. et al. (2013) Cultivation-dependent plasticity of melanoma phenotype. Tumour Biol 34(6): 3345-3355