Anti-LPAM-1 antibodies, mouse

Anti-LPAM-1 antibodies, mouse

Clone: REA457 | Dilution: 1:50
Clone REA457 recognizes the mouse Peyer’s patch adhesion molecule 1 (LPAM-1) antigen, a heterodimeric glycoprotein receptor, which is also known as α4β7 integrin. LPAM-1 is a cell surface adhesion molecule involved in lymphocyte trafficking and lymphocyte-cell and matrix interactions. It is expressed on T and B cells. Lymphocytes in spleen and mesenteric lymph nodes have low levels of LPAM-1 expression but can up-regulate their LPAM-1 expression on activation. Cellular ligands include vascular cell adhesion molecule 1 (VCAM-1) and the mucosal addressin cell adhesion molecule 1 (MAdCAM-1), which is present on high endothelial venules of mucosal lymphoid organs. Interaction of LPAM-1 with MAdCAM-1 allows for tissue-specific migration of circulating lymphocytes into the lamina propria and Peyer patches of the gut.
Additional information: Clone REA457 displays negligible binding to Fc receptors.

Alternative names

ITGA4, M290 IEL, Itga4B, Ly69, ITGB7, CD49d

Technical specifications

  • Antigen: LPAM-1
  • Clone: REA457
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ITGA4, M290 IEL, Itga4B, Ly69, ITGB7, CD49d
  • Entrez Gene ID: 16401, 16421
  • Molecular mass of antigen [kDa]: 197
  • Distribution of antigen: T cells, B cells, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE
  • Selected references

    1. Petrovic, A. et al. (2004) LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood 103(4): 1542-1547
    2. Leung, E. et al. (1993) The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290. Int. Immunol. 5(5): 551-558
    3. Reese, S. R. et al. (2005) l-selectin and alpha4beta7 integrin, but not ICAM-1, regulate lymphocyte distribution in gut-associated lymphoid tissue of mice. Surgery 137(2): 209-215
Product options: 2
30 µg in 200 µL (1)
30 µg in 200 µL (1)

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