Clone:
REA241
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Klra8, Cmv-1, Cmv1

Specifications for Ly-49H Antibody, anti-mouse, REAfinity™

Overview

Clone REA241 recognizes mouse lymphocyte antigen 49H (Ly-49H) which is also known as killer cell lectin-like receptor 8, Klra8, or Cmv-1. REA241 does not crossreact with related molecules like Ly-49A, C, D, or G2. Ly-49H is a member of the C-type lectin Ly-49 multigene family and is expressed by C57BL/6 and NWNA but not by BALB/c and DBA/2 mouse NK cells. It recognizes a ligand from mouse cytomegalovirus (MCMV), and engagement of Ly-49H can lead to killing of MCMV-infected cells. In addition to NK cell cytotoxicity, Ly-49H has a crucial role in supporting NK cell proliferation to prevent immunopathology caused by the adaptive immune system.
Additional information: Clone REA241 displays negligible binding to Fc receptors.

Alternative names

Klra8, Cmv-1, Cmv1

Detailed product information

Technical specifications

CloneREA241
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49H
Alternative names of antigenKlra8, Cmv-1, Cmv1
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells
Entrez Gene ID16639
RRIDAB_2652763, AB_2652764, AB_2652765, AB_2652766, AB_2652767, AB_2652768, AB_2652769, AB_2652770, AB_2652771, AB_2652772, AB_2652773, AB_2652774, AB_2652775, AB_2652776

References for Ly-49H Antibody, anti-mouse, REAfinity™

Publications

  1. Smith, K. M. et al. (1989) Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 161: 7-10
  2. Seung-Hwan, L. et al. (2003) Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J. Exp. Med. 197(4): 515-526
  3. Seung-Hwan, L. et al. (2009) Activating receptors promote NK cell expansion for maintenance, IL10 production, and CD8 T cell regulation during viral infection. J. Exp. Med. 206: 2235-2251

Related products for
Ly-49H Antibody, anti-mouse, REAfinity™

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?