Clone:
REA1020
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Klra4, Chok, Klra32, Klra33, Ly-49d

Specifications for Ly-49D Antibody, anti-mouse, REAfinity™

Overview

Clone REA1020 recognizes Ly-49D, a type II transmembrane NK cell receptor belonging to the Ly-49 family. Members of the Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49D is a prototypic activating member of the Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. Expression of Ly-49D is strain restricted and is found on subsets of NK cells in C57BL/6, C3H/He, and SJL but not in BALB/c, DBA/2, AKR, and CBA/J mice.
Additional information: Clone REA1020 displays negligible binding to Fc receptors.

Alternative names

Klra4, Chok, Klra32, Klra33, Ly-49d

Detailed product information

Technical specifications

CloneREA1020
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49D
Alternative names of antigenKlra4, Chok, Klra32, Klra33, Ly-49d
Molecular mass of antigen [kDa]31
Distribution of antigendendritic cells, macrophages, NK cells, T cells, basophils, eosinophils, neutrophils, NKT cells
Entrez Gene ID16635
RRIDAB_2727886, AB_2727849, AB_2727887, AB_2727850

References for Ly-49D Antibody, anti-mouse, REAfinity™

Publications

  1. Yokoyama, W. M. et al. (1993) The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11: 613-635
  2. Mason, L. H. et al. (1996) The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184: 2119-2128
  3. Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11(1): 67-77

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