Clone:
REA862
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
AMICA1, junctional adhesion molecule-like

Specifications for JAML Antibody, anti-mouse, REAfinity™

Overview

Clone REA862 recognizes the mouse JAML antigen, also known as AMICA1 or junctional adhesion molecule-like protein. JAML is a transmembrane protein, which consists of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling. JAML is found on γ/δ intraepithelial T cells. The costimulatory molecule JAML binds to its ligands Coxsackie virus and adenovirus receptor (CAR), that leads to cellular proliferation and cytokine and growth factor production.
Additional information: Clone REA862 displays negligible binding to Fc receptors.

Alternative names

AMICA1, junctional adhesion molecule-like

Detailed product information

Technical specifications

CloneREA862
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenJAML
Alternative names of antigenAMICA1, junctional adhesion molecule-like
Molecular mass of antigen [kDa]40
Distribution of antigenT cells
Entrez Gene ID270152
RRIDAB_2726744, AB_2726660, AB_2726745, AB_2726661, AB_2726743, AB_2726659

References for JAML Antibody, anti-mouse, REAfinity™

Publications

  1. Zen, K. et al. (2005) Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol. Biol. Cell 16(6): 2694-2703
  2. Witherden, D. A. et al. (2010) The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science 329(5996): 1205-1210

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