Clone:
REA700
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1

Extended validation for Jak1 Antibody, anti-human/mouse/rat, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA700
413104++
Cells were incubated with an excess of purified unconjugated Jak1 (REA700) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for Jak1 Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA700 recognizes the human, mouse, and rat Jak1 antigen, also known as tyrosine-protein kinase JAK1 or janus kinase 1. Jak1 is a widely expressed membrane-associated phosphoprotein characterized by the presence of a second phosphotransferase-related domain immediately N terminal to the PTK domain. Jak1 is involved in the IFN-α/β/γ signal pathway and activates transcription factors of the STAT family by phosphorylating critical tyrosine regulatory sites.
Additional information: Clone REA700 displays negligible binding to Fc receptors

Alternative names

Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1

Detailed product information

Technical specifications

CloneREA700
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
AntigenJak1
Alternative names of antigenTyrosine-protein kinase JAK1, Janus kinase 1, JAK-1
Molecular mass of antigen [kDa]133(same molecular weight for human and mouse/rat)
Distribution of antigenubiquitous
Entrez Gene ID3716, 16451, 84598
RRIDAB_2652545, AB_2652546, AB_2652547, AB_2652544

References for Jak1 Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Wilks, A. F. et al. (1991) Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11(4): 2057-2065
  2. Williams, N. K. et al. (2009) Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase Domains. J. Mol. Biol. 387(1): 219-232

Related products for
Jak1 Antibody, anti-human/mouse/rat, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?