Clone:
REA310
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C

Specifications for IRF-7 pS477/pS479 Antibody, anti-human, REAfinity™

Overview

Clone REA310 recognizes the interferon regulatory factor 7 (IRF-7) phosphorylated at serines 477 and 479 (pS477/pS479). IRF-7 is a member of the IRF family of transcription factors and a key player in the innate immune response against viral infections. Constitutive expression of IRF-7 is limited to peripheral blood lymphocytes and dendritic cells while in most cell types its expression can be induced by type I interferon. IRF-7 is sequestered in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, it becomes phosphorylated by TBK and IKK-i kinases. Phosphorylated IRF-7 migrates in the nucleus where it can activate interferon type I genes and other interferon-stimulated genes.
Additional information: Clone REA310 displays negligible binding to Fc receptors.

Alternative names

IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C

Detailed product information

Technical specifications

CloneREA310
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenIRF-7 pS477/pS479
Alternative names of antigenIRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C
Molecular mass of antigen [kDa]54
Distribution of antigendendritic cells, lymphocytes
Entrez Gene ID3665
RRIDAB_2652526, AB_2652527, AB_2652528, AB_2652529, AB_2652530, AB_2652531

References for IRF-7 pS477/pS479 Antibody, anti-human, REAfinity™

Publications

  1. Sgarbanti, M. et al. (2007) IRF-7: new role in the regulation of genes involved in adaptive immunity. Ann. N. Y. Acad. Sci. 1095: 325-333
  2. Smith, E. J. et al. (2001) IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J. Biol. Chem. 276(12): 8951-8957
  3. Zhang L. et al. (1997) IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency. Mol. Cell. Biol. 17(10): 5748-5757
  4. Zuniga El et al. (2017) Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses. Nat Commun. 8: 14830

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