Clone:
TC11-18H10
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG1κ, rat IgG1
Applications:
ICFC, FA
Alternative names:
CTLA-8, IL-17

Specifications for IL-17A Antibody, anti-mouse

Overview

The Anti-IL-17A antibodies are designed for intracellular staining of IL-17A–producing cells.
Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders.
1
Data from several mouse models suggest that IL-17 plays a key role in the host defense against certain extracellular bacterial infections.
Recently, a new mouse T helper cell subset has been identified, which is distinct from Th1 and Th2 cells: IL-17–producing CD4
+
T helper (Th17) cells. Th17 cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. Receptors for IL-17 and IL-22 are expressed on various epithelial tissues, thus Th17 cells are crucial for the cross-talk between immune system and tissues.
2
It is now established that Th17 cells are responsible for driving autoimmune inflammation.
After stimulation of mouse T cells, IL-17 is not only secreted by CD4
+
T cells, but also by CD8
+
T cells and γδ T cells.

Alternative names

CTLA-8, IL-17

Detailed product information

Technical specifications

CloneTC11-18H10
Clonalitymonoclonal
Isotyperat IgG1, rat IgG1κ
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenIL-17A
Alternative names of antigenCTLA-8, IL-17
Molecular mass of antigen [kDa]15
Entrez Gene ID16171
RRIDAB_10828821, AB_2660785, AB_2660786, AB_2660787, AB_2660788, AB_2819523

References for IL-17A Antibody, anti-mouse

Publications

  1. Ouyang, W. et al. (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467
  2. Weaver, C. T. et al. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852

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