Clone:
REA200
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL12RB2, IL-12RB2, Ifnm

Specifications for IL-12R β2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA200 recognizes the mouse Interleukin-12 receptor subunit beta-2 (IL-12R β2) antigen, a Single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon gamma. IL-12R β2 is expressed by Th1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL-12R β2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Additional information: Clone REA200 displays negligible binding to Fc receptors.

Alternative names

IL12RB2, IL-12RB2, Ifnm

Detailed product information

Technical specifications

CloneREA200
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-12R β2
Alternative names of antigenIL12RB2, IL-12RB2, Ifnm
Molecular mass of antigen [kDa]96
Distribution of antigenT cells
Entrez Gene ID16162
RRIDAB_2652346, AB_2652344, AB_2652345, AB_2652347, AB_2652350, AB_2652351

References for IL-12R β2 Antibody, anti-mouse, REAfinity™

Publications

  1. Nishikomori, R. et al. (2002) Activated STAT4 has an essential role in Tʜ1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J. Immunol. 169(8): 4388-4398
  2. Yin, Z. et al. (2000) Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. J. Immunol. 164(6): 3056-3064
  3. Presky, D. H. et al. (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U.S.A. 93(24): 14002-14007

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