Clone:
REA333
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL12RB2

Specifications for IL-12R β2 Antibody, anti-human, REAfinity™

Overview

Clone REA333 recognizes the human interleukin 12 (IL-12) receptor subunit beta-2 (IL-12R β2) antigen, a single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon γ. IL-12R β2 is expressed by Tʜ1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Tʜ1 differentiation. The IL-12R β2 subunit plays an important role in Tʜ1 cell differentiation, since its absence leads to an abortive Tʜ1 differentiation that has dysfunctional production of Tʜ1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Additional information: Clone REA333 displays negligible binding to Fc receptors.

Alternative names

IL12RB2

Detailed product information

Technical specifications

CloneREA333
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenIL-12R β2
Alternative names of antigenIL12RB2
Molecular mass of antigen [kDa]95
Distribution of antigenT cells
Entrez Gene ID3595
RRIDAB_2751988, AB_2652356, AB_2652357, AB_2752018

References for IL-12R β2 Antibody, anti-human, REAfinity™

Publications

  1. Nishikomori, R. et al. (2002) Activated STAT4 has an essential role in Tʜ1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J. Immunol. 169(8): 4388-4398
  2. Salomon, D. R. et al. (2017) H3K27 methylation dynamics during CD4 T cell activation: regulation of JAK/STAT and IL12RB2 Eexpression by JMJD3. J. Immunol. 199(9): 3158-3175
  3. Yin, Z. et al. (2000) Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. J. Immunol. 164(6): 3056-3064
  4. Presky, D. H. et al. (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U.S.A. 93(24): 14002-14007

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