Clone:
REA121
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
IL12A, CLMF, IL-12A, NFSK, NKSF1, P35

Specifications for IL-12 (p35/p70) Antibody, anti-human, REAfinity™

Overview

Interleukin-12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages as well as dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity: It induces the production of IFN-γ alone or in synergy with IL-2, is a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (Tʜ1)-specific immune responses by promoting the differentiation of CD4
+
cells towards a Tʜ1 phenotype while inhibiting the production of Tʜ2 cells. The antibody clone REA121 reacts with the p35 kDa chain and the p70 kDa heterodimer of human IL-12, but not with IL-12 p40. It recognizes the same epitope as clone B-T21.
Additional information: Clone REA121 displays negligible binding to Fc receptors.

Alternative names

IL12A, CLMF, IL-12A, NFSK, NKSF1, P35

Detailed product information

Technical specifications

CloneREA121
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenIL-12 (p35/p70)
Alternative names of antigenIL12A, CLMF, IL-12A, NFSK, NKSF1, P35
Molecular mass of antigen [kDa]22
Distribution of antigenmacrophages, monocytes, dendritic cells
Entrez Gene ID3592
RRIDAB_2652323, AB_2652324, AB_2652325, AB_2652326, AB_2652327, AB_2652328, AB_2652329, AB_2652330, AB_2652322, AB_2652321

References for IL-12 (p35/p70) Antibody, anti-human, REAfinity™

Publications

  1. D´Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176: 1387-1398
  2. Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3(2): 133-146

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