Clone:
REA995
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
IGHA2

Extended validation for IgA2 Antibody, anti-human, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA995
A9604D2++
IS11-21E11++
Cells were incubated with an excess of purified unconjugated IgA2 (REA995) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for IgA2 Antibody, anti-human, REAfinity™

Overview

Clone REA995 detects the IgA2 subclass of human immunoglobulin. IgA is present either as monomer or in a secreted form as a multimer of 2–4 molecules, connected by the J-chain and the so-called secretory component. Secreted IgA is transported across epithelial cells and secreted into the lumen of the respiratory and gastrointestinal tract. IgA2 is produced by B cells in the mucosae and is the most abundant immunoglobulin in mucosal secretions.
Additional information: Clone REA995 displays negligible binding to Fc receptors.

Alternative names

IGHA2

Detailed product information

Technical specifications

CloneREA995
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenIgA2
Alternative names of antigenIGHA2
Distribution of antigenB cells
Entrez Gene ID3494
RRIDAB_2728061, AB_2728035, AB_2728062, AB_2728036, AB_2728063, AB_2728037

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