Clone:
REA1013
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MC
Alternative names:
IFNA1

Specifications for IFN-α Antibody, anti-human, REAfinity™

Overview

Type I interferons (IFNs), including IFN-α, are a family of cytokines that exert pleiotropic functions in the immune system. Besides its potent antiviral activity, IFN-α exerts a variety of immunomodulatory effects, including positive and negative regulation of its own production, regulation of IL-12 and IFN-γ production, promotion of natural killer (NK) cell cytotoxicity, activation and maturation of dendritic cells, and the promotion of B cell development towards plasma cells. IFN-α is expressed predominantly by CD123+CD11c-CD303 (BDCA2)+ plasmacytoid dendritic cells (pDCs). Clone REA1013 recognizes the majority of the IFN-α subtypes, including IFN-α2b.
Additional information: Clone REA1013 displays negligible binding to Fc receptors.

Alternative names

IFNA1

Detailed product information

Technical specifications

CloneREA1013
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenIFN-α
Alternative names of antigenIFNA1
Molecular mass of antigen [kDa]20
Distribution of antigendendritic cells, plasmacytoid dendritic cells
Entrez Gene ID3439, 3444, 3443, 3449, 3442, 3448, 3446, 3441, 3452, 3447, 3445, 3451, 3440
RRIDAB_2727733, AB_2727804, AB_2727734, AB_2727805, AB_2727735, AB_2727806, AB_2727736, AB_2727732, AB_2727803, AB_2727802

References for IFN-α Antibody, anti-human, REAfinity™

Publications

  1. Ronnblom, L. and Alm, G. V. (2001) An etiopathogenic role for the type I IFN system in SLE. Trends Immunol. 22: 427-431
  2. Båve, U. et al. (2003) Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171(6): 3296-3302

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