Alternative names:
TNFSF11, TRANCE, ODF

Specifications for Human RANK-Ligand – soluble

Overview

RANK-Ligand - soluble stands for receptor activator of NF-κB ligand, soluble. Human RANK-Ligand - soluble is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human RANK-Ligand – soluble can be used for a variety of applications, including:
  • In vitro differentiation of monocytes to osteoclasts, together with M-CSF.
  • Study of cell-receptor signaling of tumor necrosis factor receptor family.
  • Investigation in immune cell activation, osteogenesis, and tumor growth.

Alternative names

TNFSF11, TRANCE, ODF

Detailed product information

Background information

Receptor activator of nuclear factor kappa-B (RANK) ligand, also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), together with RANK, is a member of the TNF superfamily of ligands and receptors involved in activation of immune response and in bone regeneration. RANK-Ligand is expressed in several tissues and cell types, including fibroblasts, T cells, and osteoblasts, and functions by binding its cell surface signaling receptor RANK. RANK-Ligand is expressed by T helper cells and is involved in dendritic cell maturation. Binding of osteoprotegerin (OPG) by RANK-Ligand inhibits osteoclastogenesis and leads to accumulation of bone and cartilage. High expression of RANK-Ligand is observed during degenerative bone diseases and in tumors. Human RANK-Ligand shares with mouse 85% amino acid identity and is reactive on murine cells.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human RANK-Ligand – soluble

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

Seems like you are coming from USA!
Do you want to visit our website in your country?