Clone:
REA138
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
HLA-B, AS, SPDA1

Specifications for HLA-B12 Antibody, anti-human, REAfinity™

Overview

Clone REA138 recognizes HLA B12, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA138 displays negligible binding to Fc receptors.

Alternative names

HLA-B, AS, SPDA1

Detailed product information

Technical specifications

CloneREA138
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-B12
Alternative names of antigenHLA-B, AS, SPDA1
Distribution of antigenB cells, granulocytes, macrophages, dendritic cells, endothelial cells, NK cells, T cells
Entrez Gene ID3106
RRIDAB_2652097, AB_2652098, AB_2652108, AB_2652099, AB_2652100, AB_2652101, AB_2652102, AB_2652103, AB_2652104, AB_2652105, AB_2652106, AB_2652107, AB_2652109, AB_2652110

References for HLA-B12 Antibody, anti-human, REAfinity™

Publications

  1. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169

Related products for
HLA-B12 Antibody, anti-human, REAfinity™

3 products available