Clone:
REA722
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Endothelial cell-selective adhesion molecule, ESAM1

Specifications for ESAM Antibody, anti-mouse, REAfinity™

Overview

Clone REA722 recognizes the mouse endothelial cell-selective adhesion molecule (ESAM) antigen, a 55 kDa molecule, which is also known as a transmembrane tight junction protein composed of a single transmembrane domain and a cytoplasmic domain. By affecting endothelial cell contacts, ESAM is mostly expressed on endothelial cells of various organs such as heart, lung, kidney, and skin, participating in the migration of neutrophils through the vessel wall.
Additional information: Clone REA722 displays negligible binding to Fc receptors.

Alternative names

Endothelial cell-selective adhesion molecule, ESAM1

Detailed product information

Technical specifications

CloneREA722
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenESAM
Alternative names of antigenEndothelial cell-selective adhesion molecule, ESAM1
Molecular mass of antigen [kDa]39
Distribution of antigenother, heart, kidney, lung, skin
Entrez Gene ID69524
RRIDAB_2651689, AB_2651690, AB_2651691, AB_2651692, AB_2651693, AB_2651694, AB_2651695, AB_2651696, AB_2651697, AB_2651698, AB_2651699, AB_2651688

References for ESAM Antibody, anti-mouse, REAfinity™

Publications

  1. Hirata, K. et al. (2001) Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. J. Biol. Chem. 276(19): 16223-16231
  2. Nasdala, I. et al. (2002) A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. J. Biol. Chem. 277(18): 16294-16303
  3. Wegmann, F. et al. (2004) Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Exp. Cell Res. 300(1): 121-133

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