Clone:
REA501
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Emb, Gp70

Specifications for Embigin Antibody, anti-mouse, REAfinity™

Overview

Clone REA501 recognizes the mouse embigin antigen, a single-pass type I membrane protein, which is also known as teratocarcinoma glycoprotein Gp-70. Embigin is a developmentally expressed protein that is a member of the immunoglobulin superfamily class of cell adhesion molecules (CAMs). It is strongly expressed in mouse embryos between five and nine days of gestation but only weakly in adult organs. Embigin plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, embigin promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting the terminal Schwann cell number or their morphology.
Additional information: Clone REA501 displays negligible binding to Fc receptors.

Alternative names

Emb, Gp70

Detailed product information

Technical specifications

CloneREA501
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenEmbigin
Alternative names of antigenEmb, Gp70
Molecular mass of antigen [kDa]34
Distribution of antigenstem cells, T cells, Schwann cells, myeloid leukemia cells, hematopoietic stem and progenitor cells
Entrez Gene ID13723
RRIDAB_2651622, AB_2651623, AB_2651626, AB_2651627, AB_2751395

References for Embigin Antibody, anti-mouse, REAfinity™

Publications

  1. Huang, R. P. et al. (1993) Embigin, a member of the immunoglobulin superfamily expressed in embryonic cells, enhances cell-substratum adhesion. Dev. Biol. 155(2): 307-314
  2. Huang, R. P. et al. (1990) Developmentally regulated expression of embigin, a member of the immunoglobulin superfamily found in embryonal carcinoma cells. Differentiation 45(2): 76-83
  3. Lain, E. et al. (2009) A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction. J. Biol. Chem. 284(13): 8930-8939

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