Clone:
SKa5-3D5
Type of antibody:
Primary antibodies
Isotype:
rat IgG2b
Applications:
FC
Alternative names:
CLEC4b2, APLRA1

Specifications for DCAR1 Antibody, anti-mouse

Overview

Dendritic cell immunoactivating receptor 1 (DCAR1) belongs to a subfamily of cell surface C-type lectin receptors (CLR). Mouse DCAR1 shows a tissue specific expression pattern: it is expressed on CD8a
+
DC subsets in spleen and thymus and on subsets of CD11b
+
myeloid cells in bone marrow and spleen. Mouse DCAR1 has neither been detected in lymph nodes nor in peripheral blood. Antigen delivered via anti-DCAR1 antibody is internalized and is cycled through the early and late endosomal compartment, inducing cellular and humoral responses
in vivo
. Triggering DCAR1 via monoclonal antibody ligation on CD8
+
DCs increases the secretion of bioactive IL-12 whereas secretion of IL-10 is markedly reduced, indicating that antigen recognized by mDCAR1 induces enhanced proinflammatory responses. Anti-DCAR1 antibodies have been tested on BALB/c and C57BL/6 mice.

Alternative names

CLEC4b2, APLRA1

Detailed product information

Technical specifications

CloneSKa5-3D5
Clonalitymonoclonal
Isotyperat IgG2b
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenDCAR1
Alternative names of antigenCLEC4b2, APLRA1
Molecular mass of antigen [kDa]24
Entrez Gene ID69810
RRIDAB_2661338, AB_2661339, AB_2661337

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