Clone:
REA1141
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC

Specifications for Cytokeratin 5/6/8/17/19 Antibody, anti-human, REAfinity™

Overview

Clone REA1141 recognizes cytokeratin 5, 6, 8, 17, 19. Cytokeratins, which are found in almost all epithelial cells, are polypeptides with keratin-containing intermediate filaments, which ensure form stability and cohesiveness. Keratins play a critical role in mechanical stability and integrity of epithelial cells and tissues, have regulatory functions and are involved in intracellular signaling pathways. Cytokeratin 6 is located in proliferating squamous epithelium, whereas Cytokeratin 5 is found in the basal, the intermediate and the superficial cell layers of stratified and transitional epithelia, complex epithelia, and in mesothelial cells and mesothelioma, but not in simple epithelia and in non-epithelial cells. Cytokeratin 8, an intermediate filament protein, which is found in epithelial and carcinoma cells. In adult tissues Cytokeratin 8 is expressed as a heterodimer with Cytokeratin 18. Keratin 17, a type I cytokeratin, is located in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. The type I cytokeratin 19 is found in the periderm, the transiently superficial layer that envelops the developing epidermis.
Additional information: Clone REA1141 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA1141
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCytokeratin 5/6/8/17/19
Molecular mass of antigen [kDa]55(average of subunits)
Distribution of antigenepithelial cells, tumor cells, other
Entrez Gene ID3872, 286887, 3854, 3856, 3853, 3852, 3880
RRIDAB_2857502, AB_2857503, AB_2857501

References for Cytokeratin 5/6/8/17/19 Antibody, anti-human, REAfinity™

Publications

  1. Schweizer, J. et al. (2006) New consensus nomenclature for mammalian keratins. J. Cell Biol. 174(2): 169-174