Clone:
REAL753
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
KRT20, Keratin type I cytoskeletal 20, CK-20, Keratin-20, K20, Protein IT, CK20, Keratin 20

Specifications for Cytokeratin 20 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL753 is an antibody fragment derived from the full Cytokeratin 20 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL753 recognizes the Cytokeratin 20 protein, also known as Keratin 20 or CK20, that belongs to the intermediate filament family. It plays a significant role in maintaining keratin filament organization in intestinal epithelia. Cytokeratin 20 is expressed mostly in the intestinal epithelium such as in colonic mucosa and Merkel cells and functions as imunohistology diagnostic marker for adenocarcinoma arising from epithelia.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

KRT20, Keratin type I cytoskeletal 20, CK-20, Keratin-20, K20, Protein IT, CK20, Keratin 20

Detailed product information

Technical specifications

CloneREAL753
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCytokeratin 20
Alternative names of antigenKRT20, Keratin type I cytoskeletal 20, CK-20, Keratin-20, K20, Protein IT, CK20, Keratin 20
Distribution of antigenepithelial cells, tumor cells, other, colon
RRIDAB_2877036

References for Cytokeratin 20 Antibody, anti-human, REAdye_lease™

Publications

  1. Moll, R. et al. (1992) Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am. J. Pathol. 140(2): 427-447
  2. Moll, R. et al. (1993) The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. Differentiation 53(2): 75-93
  3. Chu, P. et al. (2000) Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod. Pathol. 13(9): 962-972

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