Clone:
REA751
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CPE-R 2, hRVP1, CLDN3, C7orf1, CPETR2

Specifications for Claudin-3 Antibody, anti-human, REAfinity™

Overview

Clone REA751 recognizes the human claudin-3 antigen, an integral membrane protein which is a component of the claudin family of epithelial tight junction proteins. Claudin-3 is involved in tight junction-specific obliteration of the intercellular space. It is a low-affinity receptor for
Clostridium perfringens
enterotoxinin (CPE). Binding of CPE to claudin-3 induces epithelial cell lysis.
Additional information: Clone REA751 displays negligible binding to Fc receptors.

Alternative names

CPE-R 2, hRVP1, CLDN3, C7orf1, CPETR2

Detailed product information

Technical specifications

CloneREA751
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenClaudin-3
Alternative names of antigenCPE-R 2, hRVP1, CLDN3, C7orf1, CPETR2
Distribution of antigenepithelial cells
RRIDAB_2651416, AB_2651417, AB_2651418, AB_2651419, AB_2651420, AB_2651415

References for Claudin-3 Antibody, anti-human, REAfinity™

Publications

  1. Morita, K. et al. (1999) Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc. Natl. Acad. Sci. U.S.A. 96(2): 511-516
  2. Furuse, M. et al. (1999) Manner of interaction of heterogeneous claudin species within and between tight junction strands. J. Cell Biol. 147(4): 891-903
  3. Coyne, C. B. et al. (2003) Role of claudin interactions in airway tight junctional permeability. Am. J. Physiol. Lung Cell Mol. Physiol. 285(5): 1166-1178

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