The CD90 MicroBeads, human were developed for the positive selection or depletion of cells expressing human CD90 antigen, e.g., liver cancer stem cells from single cell suspensions from solid tumors or cancer cell lines.

Data and images for CD90 MicroBeads, human

Figures

Figure 1

Unseparated fraction
CD90
+
cells
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Figure 1

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Figure 1

Specifications for CD90 MicroBeads, human

Overview

The CD90 MicroBeads, human were developed for the positive selection or depletion of cells expressing human CD90 antigen, e.g., liver cancer stem cells from single cell suspensions from solid tumors or cancer cell lines.

Detailed product information

Background information

The CD90 antibody reacts with the human CD90 antigen, also known as Thy-1. CD90 was identified as a marker for cancer stem cells in human liver cancer
1
. In addition to cancer stem cells, it is expressed on embryonic stem cells (ESC), induced pluripotent stem cells (iPSC), neurons, small subsets of human fetal liver cells and thymocytes, cord blood and bone marrow cells. CD90 is also expressed on a subset of CD34
+
primitive hematopoietic stem cells. CD90
+
CD34
+
cells characterize a highly enriched population of high proliferative potential colony-forming cells (HPP-CFC)
2
. Furthermore, CD90 expression is found on mesenchymal stem cells (MSCs)
3
.

Columns

For positive selection: MS, LS, or autoMACS
®
Columns. For depletion: LD or autoMACS Columns.

Resources for CD90 MicroBeads, human

Documents and Protocols

References for CD90 MicroBeads, human

Publications

  1. Zhen Fan Yang, Z. F. et al. (2008)
    Significance of CD90
    +
    cancer stem cells in human liver cancer.
    Cancer Cell 13: 153-166
  2. Mayani, H. and Lansdorp, P. M. (1994) Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood. Blood 83: 2410-2417
  3. Dominici, M. et al. (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317

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