Clone:
REA234
Type of antibody:
Functional-grade antibodies, Recombinant antibodies, Primary antibodies
Isotype:
recombinant human IgG1
Applications:
FA, FC, MICS, IF, IHC
Alternative names:
FCAR, CTB-61M7.2, FcαRI

Specifications for CD89 Antibody, anti-human, REAfinity™

Overview

Clone REA234 recognizes CD89, the human myeloid IgA Fc receptor. CD89 is a glycosylated transmembrane protein that binds both IgA subclasses (IgA1 and IgA2) and is closely related to the KIR and MIR proteins rather than to other human Fc receptors. CD89 itself lacks the canonical signal transduction domains, however it associates with the FcR γ-chain with an immunoreceptor tyrosine-based activation (ITAM) motif, which allows transduction of activation signal upon ligand binding. FcαRI alone mediates endocytosis and recyling of IgA. Expression of CD89 is found on neutrophils, eosinophils, monocytes/macrophages, dendritic cells, and Kupffer cells.
Additional information: Clone REA234 displays negligible binding to Fc receptors.

Alternative names

FCAR, CTB-61M7.2, FcαRI

Detailed product information

Technical specifications

CloneREA234
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies, Functional-grade antibodies
Specieshuman
AntigenCD89
Alternative names of antigenFCAR, CTB-61M7.2, FcαRI
Distribution of antigendendritic cells, macrophages, monocytes, eosinophils
RRIDAB_2659459, AB_2659460, AB_2659463, AB_2659464, AB_2659465, AB_2659466, AB_2659467, AB_2659468, AB_2659469, AB_2659470, AB_2659458

References for CD89 Antibody, anti-human, REAfinity™

Publications

  1. Wu, J. et al. (2007) FcαRI (CD89) alleles determine the proinflammatory potential of serum IgA. J. Immunol. 178: 3973-3982
  2. Morton, H. C. et al. (1995) Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR chain. J. Biol. Chem. 270: 29781-29787

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