Clone:
REA1206
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
C5AR1, C5a-R, C5AR, C5R1

Specifications for CD88 (C5AR) Antibody, anti-mouse, REAfinity™

Overview

Clone REA1206 recognizes the mouse CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 is expressed on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on microglia and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.
Additional information: Clone REA1206 displays negligible binding to Fc receptors.

Alternative names

C5AR1, C5a-R, C5AR, C5R1

Detailed product information

Technical specifications

CloneREA1206
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD88 (C5AR)
Alternative names of antigenC5AR1, C5a-R, C5AR, C5R1
Molecular mass of antigen [kDa]39
Distribution of antigenhepatocytes, endothelial cells, epithelial cells, granulocytes, macrophages, monocytes, mast cells, astrocytes, neutrophils
Entrez Gene ID12273
RRIDAB_2811451, AB_2811452, AB_2811453, AB_2811454, AB_2811455, AB_2811456, AB_2811457, AB_2811458, AB_2811450

References for CD88 (C5AR) Antibody, anti-mouse, REAfinity™

Publications

  1. Gerard, C. et al. (1992) Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J. Immunol. 149(8): 2600-2606
  2. Sadik, C. D. et al. (2012) Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. Proc. Natl. Acad. Sci. U.S.A. 109(46): E3177-E3185
  3. Bosmann, M. et al. (2013) The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur. J. Immunol. 43(7): 1907-1913

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