Clone:
REA212
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CDw84, SLAMF5, Ly9b, GR6

Specifications for CD84 Antibody, anti-mouse, REAfinity™

Overview

Clone REA212 recognizes murine CD84, a type I transmembrane glycoprotein belonging to the SLAM (CD150) family, a CD2 subset of the Ig superfamily of cell-surface receptors. Genes encoding for SLAM members are located on the syntenic region of mouse chromosome 1 and these receptors play vital role in regulation of innate and adaptive immune responses. CD84, like other SLAM receptors has an extracellular ectodomain formed by two Ig-like domains and a cytoplasmic domain with 2 copies of the ITSM (T-I/V-Y-x-x-V/I) motif, which is a docking site for SH2-binding phosphatases and the adaptor molecules SAP and EAT-2. CD84 serves as a self ligand and displays homophilic interaction via its N-terminal Ig domain. Expression of CD84 is found on a variety of cells including B, T, mast cell, platelets, monocytes, macrophages, granulocytes, dendritic cell and Hematopoietic stem cells (HSCs). CD84 has been implicated in regulation of functions such as T cell proliferation, FcεRI-mediated signalling in mast cells, and stability of platelets aggregates.
Additional information: Clone REA212 displays negligible binding to Fc receptors.

Alternative names

CDw84, SLAMF5, Ly9b, GR6

Detailed product information

Technical specifications

CloneREA212
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD84
Alternative names of antigenCDw84, SLAMF5, Ly9b, GR6
Distribution of antigenB cells, macrophages, monocytes, platelets, T cells
RRIDAB_2659329, AB_2659330, AB_2659331, AB_2659328

References for CD84 Antibody, anti-mouse, REAfinity™

Publications

  1. Martin, M. et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-γ secretion: adhesion is mediated by Ig-like domain 1. J. Immunol. 167: 3668-3676
  2. Yan, Q. et al. (2007) Structure of CD84 provides insight into SLAM family function. Proc. Natl. Acad. Sci. U.S.A. 104: 10583-10588

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