Clone:
EAT2
Type of antibody:
Primary antibodies
Isotype:
hamster IgGκ
Applications:
FC, MICS, IF, IHC
Alternative names:
CVID6, S5.7, TAPA1, TSPAN28

Specifications for CD81 Antibody, anti-mouse/rat

Overview

CD81 is widely expressed and is involved in a variety of biological processes. In the brain it is expressed on astrocytes, oligodendrocytes, microglia, and endothelial cells. The CD81 antigen is a 26 kDa cell surface glycoprotein, also known as TAPA-1, and a member of the tetraspanin family, characterised by the presence of four hydrophobic domains. CD81 is known to complex with integrins, and mediates signal transduction events in the regulation of muscle cell fusion, myotube maintenance, signal transduction, cell development, activation, growth, and motility. The CD81 gene is localized in the tumor suppressor gene region and thus it is a candidate gene for malignancies.

Alternative names

CVID6, S5.7, TAPA1, TSPAN28

Detailed product information

Technical specifications

CloneEAT2
Clonalitymonoclonal
Isotypehamster IgGκ
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse, rat, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
AntigenCD81
Alternative names of antigenCVID6, S5.7, TAPA1, TSPAN28
Molecular mass of antigen [kDa]26
Distribution of antigenB cells, endothelial cells, epithelial cells, granulocytes, monocytes, T cells, stem cells, leukocytes, lymphocytes, ES and iPS cells
Entrez Gene ID12520
RRIDAB_2659289, AB_2659290, AB_2659291, AB_2659292, AB_2659293, AB_2659294, AB_2659295

References for CD81 Antibody, anti-mouse/rat

Publications

  1. Levy, S. et al. (1998) CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol. 16: 89-109
  2. Kelic, L. et al. (2011) CD81 regulates neuron-induced astrocyte cell-cycle exit. Mol. Cell. Neurosci. 17: 551-560

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