Clone:
2D10
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
B7, B7-1, BB1, CD28LG, CD28LG1, LAB7

Specifications for CD80 Antibody, anti-human

Overview

CD80, also known as B7-1, is a 262 amino acid long 60 kDa molecule and a member of the immunoglobulin superfamily. Together with CD86 (B7-2) it belongs to the B7 family of costimulatory molecules. CD80 is expressed on activated B cells, dendritic cells, and monocytes/ macrophages. The interaction of CD80 with its ligands CD28 and CD152 (CTLA-4) plays a critical role in induction and regulation of immune responses. Binding of CD80 to CD28, which is constitutively expressed on T cells, provides a costimulatory signal and induces T cell proliferation and cytokine production. In contrast, binding to CTLA-4 strongly inhibits proliferation and interleukin 2 (IL-2) secretion by T cells.

Alternative names

B7, B7-1, BB1, CD28LG, CD28LG1, LAB7

Detailed product information

Technical specifications

Clone2D10
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
AntigenCD80
Alternative names of antigenB7, B7-1, BB1, CD28LG, CD28LG1, LAB7
Molecular mass of antigen [kDa]29
Distribution of antigenB cells, dendritic cells, macrophages, monocytes, Langerhans cells, T cells
Entrez Gene ID941
RRIDAB_2733839, AB_2801992, AB_2801971, AB_2857834, AB_2857831, AB_2659263, AB_2733838

References for CD80 Antibody, anti-human

Publications

  1. Krummel, M. F. et al. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465
  2. Linsley, P. S. et al. (1991) Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173(3): 721-730

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