Clone:
2C9.G2 (HMβ3-1)
Type of antibody:
Primary antibodies
Isotype:
hamster IgGκ
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGB3, GP3A, INGRB3, GPIIIa

Specifications for CD61 Antibody, anti-mouse/rat

Overview

Clone 2C9.G2 (HMβ3-1) recognizes a 110 kDa integrin β chain known as CD61 or Integrin β3. Owing to multiple α/β subunit combinations, integrins form an array of heterodimeric receptors, each recognising a multitude of ligands. CD61, in association with either αv (CD51) or αIIb (CD41) integrin, binds to fibrinogen, fibronectin, von Willebrand factor, prothrombin, disintegrins and thrombospondin. Due to binding to various extracellular matrix proteins and cellular receptors, integrins play a significant role in cell adhesion and cell movement. Furthermore, a pro-apoptotic function of CD61 has been suggested using a hepatocellular carcinoma (HCC) cell line and patient tissues. Expression of CD61 is found on platelets, B cell subsets, myeloid cells, mast cells, osteoclasts, endothelium, megakaryocytes, and smooth muscle cells.

Alternative names

ITGB3, GP3A, INGRB3, GPIIIa

Detailed product information

Technical specifications

Clone2C9.G2 (HMβ3-1)
Clonalitymonoclonal
Isotypehamster IgGκ
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse, rat
AntigenCD61
Alternative names of antigenITGB3, GP3A, INGRB3, GPIIIa
Molecular mass of antigen [kDa]84
Distribution of antigenB cells, endothelial cells, fibroblasts, macrophages, mast cells, megakaryocytes, microglia, platelets, CNS cells, smooth muscle
Entrez Gene ID16416
RRIDAB_2658828, AB_2658829, AB_2658830, AB_2658831, AB_2658832, AB_2658833, AB_2658834, AB_2658835, AB_2658836, AB_2658837

References for CD61 Antibody, anti-mouse/rat

Publications

  1. Plow, E. F. et al. (2000) Ligand binding to integrins. J. Biol. Chem. 275: 21785-21788

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CD61 Antibody, anti-mouse/rat

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