Clone:
TB03
Type of antibody:
Primary antibodies
Isotype:
mouse IgMκ
Applications:
FC, MICS, IF, IHC, ICC
Alternative names:
B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1

Specifications for CD57 Antibody, anti-human

Overview

Clone TB03 specifically recognizes human CD57. CD57, also known as HNK-1 or Leu-7, is an antigenic oligosaccharide moiety detected on extracellular proteins of certain cell types. In blood, CD57 is found on 15–20% of mononuclear cells, including subsets of natural killer (NK) and T cells, though not on erythrocytes, monocytes, granulocytes, or platelets. Also, CD57 expression can be found on a variety of neural cell types.
CD57 has been shown to be expressed on late stage effector CD8
+
T cells. The frequency of CD57
+
T lymphocytes is raised in a variety of diseases. CD57 expression is also increased on chronically activated CD8
+
T cells in persistent viral infections, such as HIV.

Alternative names

B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1

Detailed product information

Technical specifications

CloneTB03
Clonalitymonoclonal
Isotypemouse IgMκ
Isotype controlIsotype Control Antibody, mouse IgM
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD57
Alternative names of antigenB3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1
Distribution of antigenB cells, NK cells, T cells, stem cells, ES and iPS cells, CNS cells, brain
RRIDAB_2784259, AB_2727643, AB_2727577, AB_2819441, AB_2819436, AB_2811537, AB_2811528, AB_2819550, AB_2819515, AB_2819560, AB_2819530, AB_2660484, AB_1036036, AB_2660488, AB_2660489, AB_1036032, AB_2784260

References for CD57 Antibody, anti-human

Publications

  1. Palmer, B. E. et al. (2005)
    Functional and phenotypic characterization of CD57
    +
    CD4
    +
    T cells and their association with HIV-1-induced T cell dysfunction.
    J. Immunol. 175: 8415-8423
  2. Brenchley, J. M. et al. (2003)
    Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8
    +
    T cells.
    Blood 101: 2711-2720
  3. Mechtersheimer, G. et al. (1991) Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors. Cancer Res. 51: 1300-1307
  4. Dupuy d'Angeac, A. et al. (1993)
    Increased percentage of CD3
    +
    , CD57
    +
    lymphocytes in patients with rheumatoid arthritis. Correlation with duration of disease.
    Arthritis Rheum. 36: 608-612
  5. Ong, E. et al. (2002)
    Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 β1,6-
    N
    -acetylglucosaminyltransferase and the muscle-specific domain in NCAM.
    J. Biol. Chem. 277: 18182-18190

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