Clone:
HMα5-1
Type of antibody:
Primary antibodies
Isotype:
hamster IgG
Applications:
FC
Alternative names:
VLA-5, Integrin alpha-5, ITGA5

Specifications for CD49e Antibody, anti-mouse/rat

Overview

Clone HMa5-1 recognizes the mouse and rat CD49e antigen, also known as integrin alpha-5, which is a protein belonging to the integrin alpha chain family. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cellmatrix interaction. Integrin alpha-5 is composed of a heavy and a light chain linked by a disulfide bond. CD49e associates non-covalently with the integrin beta-1 (CD29) forming the very late activation antigen-5 (VLA5) complex. It is expressed on different cell types including thymocytes, mast cells, activated T cells, and splenic B cells.

Alternative names

VLA-5, Integrin alpha-5, ITGA5

Detailed product information

Technical specifications

CloneHMα5-1
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse, rat
AntigenCD49e
Alternative names of antigenVLA-5, Integrin alpha-5, ITGA5
Molecular mass of antigen [kDa]110
Distribution of antigenT cells, B cells, mast cells, thymocytes
Entrez Gene ID16402
RRIDAB_2658543, AB_2658544, AB_2658545, AB_2658546, AB_2658547, AB_2658548, AB_2658549, AB_2658550, AB_2658551, AB_2658542

References for CD49e Antibody, anti-mouse/rat

Publications

  1. Holers, V. M. et al. (1989) Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II. J. Exp. Med. 169(5): 1589-1605
  2. Noto, K. et al. (1995) Identification and functional characterization of mouse CD29 with a mAb. Int. Immunol. 7: 835-842
  3. Hemler, M. E. et al. (1990) LA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8: 365-400