Clone:
5H10-27
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA5, FNRA, VLA5

Specifications for CD49e Antibody, anti-mouse

Overview

The monoclonal antibody 5H10-27 recognizes mouse CD49e, also known as integrin α5, which interacts with integrin β1 (CD29) to form the heterodimer VLA-5, the fibronectin receptor. It is expressed on activated T cells, thymocytes, mast cells, and splenic B cells and plays a role in cell-surface mediated signaling and in adhesion. The 5H10-27 antibody has been shown to inhibit VLA-5 mediated functions and promote the stimulation of CD8
+
cells
in vitro
.

Alternative names

ITGA5, FNRA, VLA5

Detailed product information

Technical specifications

Clone5H10-27
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD49e
Alternative names of antigenITGA5, FNRA, VLA5
Molecular mass of antigen [kDa]110(sum of molecular weights of heavy and light chain)
Distribution of antigenB cells, T cells
Entrez Gene ID16402
RRIDAB_2658532, AB_2658533, AB_2658536, AB_2658537, AB_2658538, AB_2658539, AB_2658540, AB_2658541

References for CD49e Antibody, anti-mouse

Publications

  1. Rich, S. et al. (1996)
    Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8
    +
    T cell growth and apoptosis.
    J. Immunol. 157: 2916-2923
  2. Noto, K. et al. (1995) Identification and functional characterization of mouse CD29 with a mAb. Int. Immunol. 7: 835-842
  3. Hemler, M. E. et al. (1990) LA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8: 365-400
  4. Yang, J. T. et al. (1996) Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins. Mol. Biol. Cell 7: 1737-1748

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