Clone:
MRα4-1
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
ITGA4, α4 integrin chain, VLA-4α chain

Specifications for CD49d Antibody, anti-rat

Overview

Clone MRα4-1 recognizes the mouse CD49d antigen, a 150 kDa integrin family member, also known as integrin α4 chain or VLA-4α chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA-4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA-4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling.

Alternative names

ITGA4, α4 integrin chain, VLA-4α chain

Detailed product information

Technical specifications

CloneMRα4-1
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesrat
AntigenCD49d
Alternative names of antigenITGA4, α4 integrin chain, VLA-4α chain
Molecular mass of antigen [kDa]116
Distribution of antigenmast cells, monocytes, dendritic cells, lymphocytes, thymocytes, basophils, eosinophils
Entrez Gene ID311144
RRIDAB_2658496, AB_2658497, AB_2658498, AB_2658499, AB_2658500, AB_2658501, AB_2658502, AB_2658503, AB_2658504, AB_2658495

References for CD49d Antibody, anti-rat

Publications

  1. Berlin, C. et al. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74(1): 185-195
  2. Fogler, W. E. et al. (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156(12): 4707-4714
  3. Tsuzuki, Y. et al. (1996) alpha 4 integrin plays a critical role in early stages of T lymphocyte migration in Peyer's patches of rats. Int. Immunol. 8(3): 287-295

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CD49d Antibody, anti-rat

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