Clone:
REA493
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, IF, IHC, MICS
Alternative names:
Itga1, VLA-1

Specifications for CD49a Antibody, anti-mouse/rat, REAfinity™

Overview

Clone REA493 recognizes the mouse and rat CD49a antigen, a 180 kDa single-pass type I membrane protein also known as integrin α1 (Itga1). CD49a binds to CD29 (integrin β1) to form the heterodimeric integrin very late antigen 1 (VLA-1), which has been found to be widely expressed on various cell types, including mesenchymal cells, epithelial cells, macrophages, NKT cells, and T cells. VLA-1 is a receptor for laminin and collagen and interacts, via the I-domain of the extracellular domain of the CD49a subunit, with collagen molecules in the extracellular matrix. CD49a expression parallels high levels of IFN-γ production in effector T cells, and CD49a has been intensively studied for its role in mediating T-cell accumulation, apoptosis, and retention within pathological tissues in immune-mediated inflammation.
Additional information: Clone REA493 displays negligible binding to Fc receptors.

Alternative names

Itga1, VLA-1

Detailed product information

Technical specifications

CloneREA493
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse, rat
AntigenCD49a
Alternative names of antigenItga1, VLA-1
Molecular mass of antigen [kDa]128
Distribution of antigenepithelial cells, macrophages, T cells, NKT cells
Entrez Gene ID25118, 109700
RRIDAB_2857710, AB_2857741, AB_2658439, AB_2658440

References for CD49a Antibody, anti-mouse/rat, REAfinity™

Publications

  1. Ben-Horin, S. et al. (2004) The role of very late antigen-1 in immune-mediated inflammation. Clin. Immunol. 113(2): 119-129
  2. Chen, Y. et al. (2014) CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production. Immunology 141(3): 388-400
  3. Gindraux, F. et al. (2007) Human and rodent bone marrow mesenchymal stem cells that express primitive stem cell markers can be directly enriched by using the CD49a molecule. Cell Tissue Res. 327(3): 471-483

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