Clone:
REA185
Type of antibody:
Primary antibodies, Recombinant antibodies, Functional-grade antibodies
Isotype:
recombinant human IgG1
Applications:
FC, FA
Alternative names:
GP1BA, BDPLT1, BDPLT3, BSS, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, gpIbα

Specifications for CD42b Antibody, anti-human, REAfinity™

Overview

Clone REA185 recognizes CD42b, a 145 kDa single-pass type I membrane protein. Expression of CD42b is found on platelets and megakaryocytes. CD42b, the α chain, together with the β chain (CD42c), forms the heterodimer, glycoprotein Ib (GP Ib). The GP Ib receptor complex further includes association of the α and β subunits with platelet glycoprotein IX and glycoprotein V and this complex serves as the receptor for von Willebrand factor (VWF). The interaction of the GP Ib-IX-V complex to VWF initiates initial platelet adhesion to vascular subendothelium after vascular injury, platelet activation, thrombosis, and hemostasis. Other known ligands for GPIb–IX–V include α-thrombin, clotting factors XI/XIIa, and high-molecularweight kininogen.
Additional information: Clone REA185 displays negligible binding to Fc receptors.

Alternative names

GP1BA, BDPLT1, BDPLT3, BSS, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, gpIbα

Detailed product information

Technical specifications

CloneREA185
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies, Functional-grade antibodies
Specieshuman
Cross-reactivity
chimpanzee (
Pan troglodytes
)
AntigenCD42b
Alternative names of antigenGP1BA, BDPLT1, BDPLT3, BSS, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, gpIbα
Molecular mass of antigen [kDa]67
Distribution of antigenmegakaryocytes, platelets, platelets, megakaryocytes
Entrez Gene ID2811
RRIDAB_2661343, AB_2658070, AB_2658071, AB_2658074, AB_2658075, AB_2658076, AB_2658077, AB_2658078, AB_2658079

References for CD42b Antibody, anti-human, REAfinity™

Publications

  1. Shrimpton, C. N. et al. (2002) Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J. Exp. Med. 196: 1057
  2. Andrews, R. K. et al. (1997) Molecular mechanisms of platelet adhesion and activation. Int. J. Biochem. Cell Biol. 29(1): 91-105
  3. Andrews, R. K. et al. (2003) Glycoprotein Ib-IX-V. Int. J. Biochem. Cell Biol. 35(8): 1170-1174

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CD42b Antibody, anti-human, REAfinity™

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