Clone:
REAL179
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF, FC
Alternative names:
gpIIb/IIIa complex, integrin αIIbβ3

Specifications for CD41/CD61 Antibody, anti-human,
REAlease
®

Overview

Clone REAL179 is an antibody fragment derived from the full CD41/CD61 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL179 recognizes the CD41/CD61 complex, also known as gpIIb/IIIa complex or integrin αIIbβ3. This cell adhesion molecule is an α/β transmembrane heterodimer of the ubiquitous integrin superfamily which is expressed by megakaryocytes and platelets. The CD41/CD61 complex plays an significant role in hemostasis and is also involved in fibrinogen binding and platelet aggregation.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

gpIIb/IIIa complex, integrin αIIbβ3

Detailed product information

Technical specifications

CloneREAL179
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD41/CD61
Alternative names of antigengpIIb/IIIa complex, integrin αIIbβ3
Distribution of antigenmegakaryocytes, platelets
RRIDAB_2751625, AB_2751581, AB_2751804, AB_2751744, AB_2751274, AB_2751268, AB_2784187, AB_2784186, AB_2784188

References for CD41/CD61 Antibody, anti-human,
REAlease
®

Publications

  1. Naik, U. P. et al. (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J. Biol. Chem. 272(8): 4651-4654
  2. Corbel, C. et al. (2005) (alpha)IIb integrin, a novel marker for hemopoietic progenitor cells. Int. J. Dev. Biol. 49(2-3): 279-284
  3. Podolnikova, N. P. et al. (2014) The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain. J. Biol. Chem. 289(4): 2371-2383

Related products for
CD41/CD61 Antibody, anti-human,
REAlease
®

3 products available