Clone:
7H11
Type of antibody:
Primary antibodies
Isotype:
rat IgG1κ
Applications:
FC
Alternative names:
DNGR-1

Specifications for CD370 (CLEC9A) Antibody, anti-mouse

Overview

Clone 7H11 recognizes CD370 C-type lectin 9A (CLEC9A), also known as DC NK lectin group receptor-1 (DNGR-1). It is a protein of 264 amino acids expressed at high level on CD8a
+
dendritic cells and at lower level on mPDCA-1
+
plasmacytoid dendritic cells. CD370 (CLEC9A) recognizes necrotic cell associated epitopes and plays an important role in crosspresentation of dead cell derived antigens.

Alternative names

DNGR-1

Detailed product information

Technical specifications

Clone7H11
Clonalitymonoclonal
Isotyperat IgG1κ
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD370 (CLEC9A)
Alternative names of antigenDNGR-1
Molecular mass of antigen [kDa]27
Distribution of antigendendritic cells
Entrez Gene ID232414
RRIDAB_2657799, AB_2657800, AB_2734067

References for CD370 (CLEC9A) Antibody, anti-mouse

Publications

  1. Sancho, D. et al. (2008) Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J. Clin. Invest. 118(6): 2098-2110
  2. Sancho, D. et al. (2009) Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240): 899-903
  3. Joffre, O. P. et al. (2010)
    Efficient and versatile manipulation of the peripheral CD4
    +
    T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
    Eur. J. Immunol. 40(5): 1255-1265

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