Clone:
REA980
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
GITR, TNFRSF18, AITR

Specifications for CD357 (GITR) Antibody, anti-mouse, REAfinity™

Overview

Clone REA980 recognizes the mouse CD357 antigen, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18. CD357 is a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Activation of T cells upregulates CD357 expression. Interaction of CD357 (GTITR) with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. CD357 plays an important role in the function of CD4
+
CD25
+
Tregs.
Additional information: Clone REA980 displays negligible binding to Fc receptors.

Alternative names

GITR, TNFRSF18, AITR

Detailed product information

Technical specifications

CloneREA980
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD357 (GITR)
Alternative names of antigenGITR, TNFRSF18, AITR
Molecular mass of antigen [kDa]23
Distribution of antigenT cells, regulatory T cells
Entrez Gene ID21936
RRIDAB_2727533, AB_2727493, AB_2727532, AB_2727492, AB_2727528, AB_2727488, AB_2727489, AB_2727530, AB_2727490, AB_2727531, AB_2727491, AB_2727529

References for CD357 (GITR) Antibody, anti-mouse, REAfinity™

Publications

  1. Nocentini, G. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 6216-6221
  2. Ronchetti, S. et al. (2002) Role of GITR in activation response of T lymphocytes. Blood 100(1): 350-352
  3. Rochetti, S. et al. (2004) GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur. J. Immunol. 34(3): 613-622

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